The endocannabinoid system is one of the body’s key regulatory networks, influencing pain, inflammation, mood, sleep and our ability to feel calm and connected. While cannabis is the best-known plant associated with this system, it is far from the only way to influence cannabinoid receptors. In this article, I explore how the endocannabinoid system works, the role of CB1 and CB2 receptors, and how herbal medicines, social connection and exercise influence this pathway without